Reaction Details | |||
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Target | Serine/threonine-protein kinase Sgk1 | ||
Ligand | BDBM50043020 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1444808 (CHEMBL3379051) | ||
IC50 | 170±n/a nM | ||
Citation | Rosse, G Novel azaindazole sulfonamides inhibitors of serum and glucocorticoid regulated kinase. ACS Med Chem Lett6:19-20 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase Sgk1 | |||
Name: | Serine/threonine-protein kinase Sgk1 | ||
Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) | ||
Type: | Other Protein Type | ||
Mol. Mass.: | 48954.40 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. | ||
Residue: | 431 | ||
Sequence: |
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BDBM50043020 | |||
n/a | |||
Name | BDBM50043020 | ||
Synonyms: | CHEMBL3355030 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H26FN5O5S | ||
Mol. Mass. | 527.568 | ||
SMILES | COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(O[C@H]2CC[C@H](O)CC2)c2c(C)n[nH]c2n1 |r,wU:23.24,wD:26.28,(46.54,-10.36,;45.77,-11.7,;46.55,-13.04,;45.79,-14.37,;46.56,-15.69,;48.1,-15.7,;48.87,-17.03,;48.87,-14.36,;48.1,-13.03,;50.41,-14.36,;51.74,-15.13,;50.41,-15.9,;51.18,-13.03,;52.72,-13.03,;53.49,-14.38,;55.03,-14.38,;55.81,-13.05,;55.03,-11.7,;53.49,-11.71,;57.34,-13.05,;58.11,-11.72,;59.65,-11.72,;60.42,-10.38,;61.96,-10.38,;62.73,-9.05,;64.28,-9.05,;65.05,-10.39,;66.59,-10.39,;64.27,-11.72,;62.73,-11.72,;60.43,-13.06,;61.93,-13.39,;63.08,-12.37,;62.08,-14.92,;60.67,-15.54,;59.65,-14.39,;58.11,-14.39,)| | ||
Structure |