Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50043652 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1445052 (CHEMBL3372984) | ||
Ki | <1.000000±n/a nM | ||
Citation | Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett6:58-62 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50043652 | |||
n/a | |||
Name | BDBM50043652 | ||
Synonyms: | CHEMBL3355537 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H21ClFN7O | ||
Mol. Mass. | 501.943 | ||
SMILES | CN1Cc2cc(Nc3ncc4c(n3)n3ccnc3n(-c3c(F)cccc3Cl)c4=O)ccc2C2(CC2)C1 |(56.61,-16.41,;55.29,-15.63,;55.3,-14.08,;53.96,-13.32,;53.96,-11.78,;52.63,-11.01,;52.63,-9.47,;51.3,-8.71,;51.3,-7.16,;49.97,-6.39,;48.64,-7.15,;48.63,-8.69,;49.96,-9.47,;47.3,-9.46,;46.98,-10.95,;45.46,-11.1,;44.85,-9.71,;45.98,-8.69,;45.98,-7.14,;44.65,-6.37,;43.31,-7.15,;43.31,-8.69,;41.98,-6.37,;41.98,-4.83,;43.31,-4.06,;44.65,-4.82,;45.97,-4.05,;47.3,-6.37,;47.31,-4.83,;51.29,-11.78,;51.29,-13.32,;52.62,-14.08,;52.62,-15.61,;51.52,-16.7,;51.12,-15.21,;53.95,-16.4,)| | ||
Structure |