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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50043634 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1445054 (CHEMBL3372986) | ||
| EC50 | 6800±n/a nM | ||
| Citation |  Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett6:58-62 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50043634 | |||
| n/a | |||
| Name | BDBM50043634 | ||
| Synonyms: | CHEMBL3355519 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H13ClN6O | ||
| Mol. Mass. | 388.81 | ||
| SMILES | Clc1ccccc1-n1c2nccn2c2nc(Nc3ccccc3)ncc2c1=O |(19.06,-2.71,;17.73,-3.49,;16.4,-2.72,;15.07,-3.49,;15.06,-5.04,;16.4,-5.81,;17.74,-5.04,;19.07,-5.81,;19.08,-7.35,;17.94,-8.37,;18.55,-9.77,;20.07,-9.61,;20.39,-8.12,;21.72,-7.36,;23.05,-8.13,;24.39,-7.37,;25.72,-8.14,;25.72,-9.68,;24.38,-10.44,;24.38,-11.98,;25.71,-12.76,;27.05,-11.98,;27.05,-10.45,;24.39,-5.82,;23.06,-5.05,;21.73,-5.81,;20.4,-5.04,;20.4,-3.5,)| | ||
| Structure | 
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