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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50043647 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1445054 (CHEMBL3372986) | ||
| EC50 | 620±n/a nM | ||
| Citation |  Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett6:58-62 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50043647 | |||
| n/a | |||
| Name | BDBM50043647 | ||
| Synonyms: | CHEMBL3355532 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H22ClN7O2 | ||
| Mol. Mass. | 511.962 | ||
| SMILES | CC(=O)N1Cc2cc(Nc3ncc4c(n3)n3ccnc3n(-c3ccccc3Cl)c4=O)ccc2C2(CC2)C1 |(69.82,-47.04,;69.82,-45.5,;71.16,-44.73,;68.49,-44.72,;68.5,-43.18,;67.17,-42.41,;67.17,-40.88,;65.84,-40.11,;65.84,-38.57,;64.51,-37.8,;64.51,-36.25,;63.18,-35.48,;61.85,-36.25,;61.84,-37.79,;63.17,-38.56,;60.51,-38.55,;60.19,-40.05,;58.67,-40.2,;58.06,-38.8,;59.19,-37.78,;59.19,-36.24,;57.86,-35.47,;56.52,-36.24,;55.19,-35.47,;55.19,-33.93,;56.52,-33.16,;57.85,-33.92,;59.18,-33.14,;60.52,-35.47,;60.52,-33.93,;64.5,-40.87,;64.49,-42.41,;65.83,-43.18,;65.82,-44.71,;64.73,-45.79,;64.33,-44.3,;67.15,-45.49,)| | ||
| Structure | 
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