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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase pim-1 | ||
| Ligand | BDBM50043689 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1445160 (CHEMBL3374860) | ||
| IC50 | 197±n/a nM | ||
| Citation |  Xu, Y; Brenning, BG; Kultgen, SG; Foulks, JM; Clifford, A; Lai, S; Chan, A; Merx, S; McCullar, MV; Kanner, SB; Ho, KK Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors. ACS Med Chem Lett6:63-7 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase pim-1 | |||
| Name: | Serine/threonine-protein kinase pim-1 | ||
| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 35681.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11309 | ||
| Residue: | 313 | ||
| Sequence: |
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| BDBM50043689 | |||
| n/a | |||
| Name | BDBM50043689 | ||
| Synonyms: | CHEMBL3355545 | US10047093, 8-48 | US10392392, Example 8-48 | US10875864, EX. 8-48 | US9416132, 8-48 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21F3N4O2 | ||
| Mol. Mass. | 406.4015 | ||
| SMILES | C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.1,wD:5.8,(2.94,-11.92,;3.72,-13.26,;2.22,-13.65,;5.06,-12.49,;6.38,-13.26,;6.38,-14.81,;5.06,-15.57,;3.72,-14.8,;7.72,-15.57,;9.05,-14.8,;9.05,-13.26,;10.38,-12.49,;11.71,-13.26,;13.17,-12.79,;14.08,-14.03,;13.17,-15.28,;13.93,-16.61,;13.14,-17.94,;13.9,-19.28,;15.44,-19.29,;16.22,-17.96,;17.76,-17.97,;18.52,-19.3,;20.06,-19.31,;17.74,-20.63,;19.2,-20.68,;15.46,-16.62,;11.71,-14.8,;10.38,-15.56,)| | ||
| Structure | 
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