Compile Data Set for Download or QSAR

Found 109 hits with Last Name = 'merx' and Initial = 's'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043692 (CHEMBL3355542 | US10047093, 8-52 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50364776 (CHEMBL1952141 | CHEMBL1952329) Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043662 (CHEMBL3355552 | US10047093, 8-56 | US10392392, Exa...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:4.3,wD:7.10,(51,-26.01,;51.77,-24.69,;50.23,-24.68,;51.78,-23.15,;53.11,-25.47,;54.44,-24.7,;55.77,-25.47,;55.77,-27.01,;54.44,-27.78,;53.11,-27.01,;57.1,-27.78,;58.44,-27.01,;58.44,-25.47,;59.76,-24.69,;61.09,-25.47,;62.56,-24.99,;63.46,-26.24,;62.56,-27.49,;63.31,-28.82,;62.53,-30.15,;63.28,-31.49,;64.82,-31.5,;65.61,-30.17,;64.85,-28.83,;67.15,-30.18,;67.91,-31.51,;67.92,-28.85,;68.68,-30.17,;61.09,-27.01,;59.76,-27.77,)| Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-29-20(28-19)18(13-26-29)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043697 (CHEMBL3355987 | US10047093, 8-63 | US10392392, Exa...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:4.3,wD:7.10,(.73,-52.37,;1.51,-51.04,;-.05,-51.03,;1.52,-49.51,;2.84,-51.82,;4.18,-51.06,;5.51,-51.82,;5.5,-53.37,;4.18,-54.14,;2.84,-53.36,;6.84,-54.14,;8.17,-53.37,;8.17,-51.83,;9.5,-51.05,;10.83,-51.83,;12.29,-51.35,;13.2,-52.6,;12.29,-53.84,;13.05,-55.17,;12.26,-56.5,;13.02,-57.84,;14.56,-57.86,;15.34,-56.52,;16.88,-56.53,;14.58,-55.19,;10.83,-53.37,;9.5,-54.13,)| Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-26-20(25-19)18(13-23-26)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043655 (CHEMBL3355557 | US10047093, 8-95 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:1.0,wD:4.7,(2.13,-40.45,;3.47,-41.22,;4.8,-40.46,;6.13,-41.22,;6.13,-42.77,;4.8,-43.54,;3.46,-42.76,;7.46,-43.54,;8.79,-42.77,;8.79,-41.23,;10.12,-40.45,;11.45,-41.23,;12.92,-40.75,;13.82,-42,;12.92,-43.24,;13.67,-44.57,;12.89,-45.9,;13.64,-47.24,;15.18,-47.26,;15.97,-45.92,;17.51,-45.93,;15.21,-44.59,;11.45,-42.77,;10.12,-43.53,)| Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-24-9-8-17(23-18(16)24)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043674 (CHEMBL3355550 | US10047093, 8-54 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:1.0,wD:4.7,(12.63,-23.03,;13.97,-23.8,;15.3,-23.04,;16.63,-23.8,;16.63,-25.35,;15.3,-26.12,;13.97,-25.34,;17.96,-26.12,;19.3,-25.35,;19.3,-23.81,;20.63,-23.03,;21.95,-23.81,;23.42,-23.33,;24.33,-24.58,;23.42,-25.83,;24.18,-27.16,;23.39,-28.48,;24.15,-29.82,;25.69,-29.84,;26.47,-28.5,;25.71,-27.17,;28.01,-28.51,;28.77,-29.85,;28.79,-27.18,;29.55,-28.51,;21.95,-25.35,;20.63,-26.11,)| Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-26-9-8-17(25-18(16)26)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043690 (CHEMBL3355544 | US10047093, 8-46 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(50.22,-3.1,;51.55,-3.88,;52.88,-3.11,;54.21,-3.88,;54.21,-5.42,;52.88,-6.19,;51.55,-5.42,;55.54,-6.19,;56.88,-5.42,;56.88,-3.88,;58.21,-3.1,;59.54,-3.88,;61,-3.4,;61.91,-4.65,;61,-5.9,;61.76,-7.23,;60.97,-8.56,;61.73,-9.9,;63.27,-9.91,;64.05,-8.58,;65.59,-8.59,;66.35,-9.93,;67.89,-9.94,;65.57,-11.25,;67.03,-11.3,;63.29,-7.24,;59.54,-5.42,;58.21,-6.18,)| Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-26-9-8-17(25-18(16)26)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043693 (CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...) Show SMILES CN1CCC(CNc2ccn3ncc(-c4cccc(OC(F)(F)F)c4)c3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-8-5-14(6-9-27)12-24-18-7-10-28-19(26-18)17(13-25-28)15-3-2-4-16(11-15)29-20(21,22)23/h2-4,7,10-11,13-14H,5-6,8-9,12H2,1H3,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50043674 (CHEMBL3355550 | US10047093, 8-54 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:1.0,wD:4.7,(12.63,-23.03,;13.97,-23.8,;15.3,-23.04,;16.63,-23.8,;16.63,-25.35,;15.3,-26.12,;13.97,-25.34,;17.96,-26.12,;19.3,-25.35,;19.3,-23.81,;20.63,-23.03,;21.95,-23.81,;23.42,-23.33,;24.33,-24.58,;23.42,-25.83,;24.18,-27.16,;23.39,-28.48,;24.15,-29.82,;25.69,-29.84,;26.47,-28.5,;25.71,-27.17,;28.01,-28.51,;28.77,-29.85,;28.79,-27.18,;29.55,-28.51,;21.95,-25.35,;20.63,-26.11,)| Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-26-9-8-17(25-18(16)26)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human Flt3 (unknown origin)				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043663 (CHEMBL3355551 | US10392392, Example 8-55 | US10875...) Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:1.1,wD:5.8,(32.77,-22.86,;33.55,-24.2,;32.05,-24.6,;34.89,-23.44,;36.21,-24.2,;36.21,-25.75,;34.89,-26.52,;33.55,-25.74,;37.55,-26.52,;38.88,-25.75,;38.88,-24.21,;40.21,-23.43,;41.54,-24.21,;43,-23.73,;43.91,-24.98,;43,-26.22,;43.76,-27.56,;42.97,-28.88,;43.73,-30.22,;45.27,-30.24,;46.05,-28.9,;45.29,-27.57,;47.59,-28.91,;48.35,-30.25,;48.37,-27.58,;49.13,-28.91,;41.54,-25.75,;40.21,-26.51,)| Show InChI InChI=1S/C20H21F3N4O/c1-19(28)8-5-15(6-9-19)25-17-7-10-27-18(26-17)16(12-24-27)13-3-2-4-14(11-13)20(21,22)23/h2-4,7,10-12,15,28H,5-6,8-9H2,1H3,(H,25,26)/t15-,19-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437028 (CHEMBL2403079) Show SMILES COc1cc(Nc2ncc(Br)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)[C@@H](C)C1 |r| Show InChI InChI=1S/C25H27BrN6O/c1-17-16-32(12-11-31(17)2)22-8-7-20(14-23(22)33-3)29-25-28-15-21(26)24(30-25)19-6-4-5-18(13-19)9-10-27/h4-8,13-15,17H,9,11-12,16H2,1-3H3,(H,28,29,30)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437028 (CHEMBL2403079) Show SMILES COc1cc(Nc2ncc(Br)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)[C@@H](C)C1 |r| Show InChI InChI=1S/C25H27BrN6O/c1-17-16-32(12-11-31(17)2)22-8-7-20(14-23(22)33-3)29-25-28-15-21(26)24(30-25)19-6-4-5-18(13-19)9-10-27/h4-8,13-15,17H,9,11-12,16H2,1-3H3,(H,28,29,30)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043658 (CHEMBL3355553 | US9416132, 8-57) Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:2.1,wD:5.8,(1.09,-33.12,;2.42,-32.35,;3.75,-33.13,;5.09,-32.36,;6.42,-33.13,;6.42,-34.68,;5.09,-35.45,;3.75,-34.67,;7.75,-35.44,;9.08,-34.67,;9.08,-33.13,;10.41,-32.35,;11.74,-33.13,;13.21,-32.66,;14.12,-33.9,;13.21,-35.15,;13.96,-36.48,;13.18,-37.81,;13.93,-39.15,;15.48,-39.16,;16.26,-37.83,;15.5,-36.49,;17.8,-37.84,;18.56,-39.18,;18.58,-36.51,;19.33,-37.84,;11.74,-34.67,;10.41,-35.43,)| Show InChI InChI=1S/C20H21F3N4O/c1-28-16-7-5-15(6-8-16)25-18-9-10-27-19(26-18)17(12-24-27)13-3-2-4-14(11-13)20(21,22)23/h2-4,9-12,15-16H,5-8H2,1H3,(H,25,26)/t15-,16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043699 (CHEMBL3355988) Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:2.1,wD:5.8,(15.02,-50.87,;16.36,-50.1,;17.69,-50.88,;19.03,-50.11,;20.36,-50.88,;20.35,-52.42,;19.03,-53.19,;17.69,-52.42,;21.69,-53.19,;23.02,-52.42,;23.02,-50.88,;24.35,-50.1,;25.68,-50.88,;27.15,-50.4,;28.05,-51.65,;27.15,-52.9,;27.9,-54.23,;27.12,-55.56,;27.87,-56.9,;29.41,-56.91,;30.2,-55.58,;31.74,-55.59,;29.44,-54.24,;25.68,-52.42,;24.35,-53.18,)| Show InChI InChI=1S/C19H21ClN4O/c1-25-16-7-5-15(6-8-16)22-18-9-10-24-19(23-18)17(12-21-24)13-3-2-4-14(20)11-13/h2-4,9-12,15-16H,5-8H2,1H3,(H,22,23)/t15-,16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437027 (CHEMBL2403080) Show SMILES COc1cc(Nc2ncc(Br)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)[C@H](C)C1 |r| Show InChI InChI=1S/C25H27BrN6O/c1-17-16-32(12-11-31(17)2)22-8-7-20(14-23(22)33-3)29-25-28-15-21(26)24(30-25)19-6-4-5-18(13-19)9-10-27/h4-8,13-15,17H,9,11-12,16H2,1-3H3,(H,28,29,30)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242411 (BDBM50043702 | US9416132, 8-96) Show SMILES N[C@H]1CCCN(C1)c1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r| Show InChI InChI=1S/C17H18ClN5/c18-13-4-1-3-12(9-13)15-10-20-23-8-6-16(21-17(15)23)22-7-2-5-14(19)11-22/h1,3-4,6,8-10,14H,2,5,7,11,19H2/t14-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437026 (CHEMBL2403056) Show SMILES COc1cc(Nc2ncc(Cl)c(n2)-c2cc(F)cc(CC#N)c2)ccc1N1CCN(C)CC1 Show InChI InChI=1S/C24H24ClFN6O/c1-31-7-9-32(10-8-31)21-4-3-19(14-22(21)33-2)29-24-28-15-20(25)23(30-24)17-11-16(5-6-27)12-18(26)13-17/h3-4,11-15H,5,7-10H2,1-2H3,(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043692 (CHEMBL3355542 | US10047093, 8-52 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437025 (CHEMBL2403057) Show SMILES COc1cc(Nc2ncc(Cl)c(n2)-c2cc(Cl)cc(CC#N)c2)ccc1N1CCN(C)CC1 Show InChI InChI=1S/C24H24Cl2N6O/c1-31-7-9-32(10-8-31)21-4-3-19(14-22(21)33-2)29-24-28-15-20(26)23(30-24)17-11-16(5-6-27)12-18(25)13-17/h3-4,11-15H,5,7-10H2,1-2H3,(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50424538 (CHEMBL2312140) Show SMILES COc1cc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)CC1 Show InChI InChI=1S/C24H25ClN6O/c1-30-10-12-31(13-11-30)21-7-6-19(15-22(21)32-2)28-24-27-16-20(25)23(29-24)18-5-3-4-17(14-18)8-9-26/h3-7,14-16H,8,10-13H2,1-2H3,(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043656 (CHEMBL3355555 | US10047093, 8-59 | US10392392, Exa...) Show SMILES FC(F)(F)c1cccc(c1)-c1cnn2ccc(NCC3CCS(=O)(=O)CC3)nc12 Show InChI InChI=1S/C19H19F3N4O2S/c20-19(21,22)15-3-1-2-14(10-15)16-12-24-26-7-4-17(25-18(16)26)23-11-13-5-8-29(27,28)9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50043697 (CHEMBL3355987 | US10047093, 8-63 | US10392392, Exa...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:4.3,wD:7.10,(.73,-52.37,;1.51,-51.04,;-.05,-51.03,;1.52,-49.51,;2.84,-51.82,;4.18,-51.06,;5.51,-51.82,;5.5,-53.37,;4.18,-54.14,;2.84,-53.36,;6.84,-54.14,;8.17,-53.37,;8.17,-51.83,;9.5,-51.05,;10.83,-51.83,;12.29,-51.35,;13.2,-52.6,;12.29,-53.84,;13.05,-55.17,;12.26,-56.5,;13.02,-57.84,;14.56,-57.86,;15.34,-56.52,;16.88,-56.53,;14.58,-55.19,;10.83,-53.37,;9.5,-54.13,)| Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-26-20(25-19)18(13-23-26)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human Flt3 (unknown origin)				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437029 (CHEMBL2403077) Show SMILES COc1cc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)C(C)C1 Show InChI InChI=1S/C25H27ClN6O/c1-17-16-32(12-11-31(17)2)22-8-7-20(14-23(22)33-3)29-25-28-15-21(26)24(30-25)19-6-4-5-18(13-19)9-10-27/h4-8,13-15,17H,9,11-12,16H2,1-3H3,(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043691 (CHEMBL3355543 | US10047093, 8-53 | US10392392, Exa...) Show SMILES N[C@H]1CCCN(C1)c1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r| Show InChI InChI=1S/C18H18F3N5O/c19-18(20,21)27-14-5-1-3-12(9-14)15-10-23-26-8-6-16(24-17(15)26)25-7-2-4-13(22)11-25/h1,3,5-6,8-10,13H,2,4,7,11,22H2/t13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043685 (CHEMBL3355549 | US10047093, 8-51 | US10392392, Exa...) Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnn2ccc(NCC3CCS(=O)(=O)CC3)nc12 Show InChI InChI=1S/C19H19F3N4O3S/c20-19(21,22)29-15-3-1-2-14(10-15)16-12-24-26-7-4-17(25-18(16)26)23-11-13-5-8-30(27,28)9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043657 (CHEMBL3355554) Show SMILES FC(F)(F)c1cccc(c1)-c1cnn2ccc(NCC3CCOCC3)nc12 Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)15-3-1-2-14(10-15)16-12-24-26-7-4-17(25-18(16)26)23-11-13-5-8-27-9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50043690 (CHEMBL3355544 | US10047093, 8-46 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(50.22,-3.1,;51.55,-3.88,;52.88,-3.11,;54.21,-3.88,;54.21,-5.42,;52.88,-6.19,;51.55,-5.42,;55.54,-6.19,;56.88,-5.42,;56.88,-3.88,;58.21,-3.1,;59.54,-3.88,;61,-3.4,;61.91,-4.65,;61,-5.9,;61.76,-7.23,;60.97,-8.56,;61.73,-9.9,;63.27,-9.91,;64.05,-8.58,;65.59,-8.59,;66.35,-9.93,;67.89,-9.94,;65.57,-11.25,;67.03,-11.3,;63.29,-7.24,;59.54,-5.42,;58.21,-6.18,)| Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-26-9-8-17(25-18(16)26)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human Flt3 (unknown origin)				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043695 (CHEMBL3355990 | US10047093, 8-66 | US10392392, Exa...) Show SMILES Clc1cccc(c1)-c1cnn2ccc(NCC3CCS(=O)(=O)CC3)nc12 Show InChI InChI=1S/C18H19ClN4O2S/c19-15-3-1-2-14(10-15)16-12-21-23-7-4-17(22-18(16)23)20-11-13-5-8-26(24,25)9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,20,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	164	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043696 (CHEMBL3355991) Show SMILES Clc1cccc(c1)-c1cnn2ccc(nc12)N1CCC(=O)CC1 Show InChI InChI=1S/C17H15ClN4O/c18-13-3-1-2-12(10-13)15-11-19-22-9-6-16(20-17(15)22)21-7-4-14(23)5-8-21/h1-3,6,9-11H,4-5,7-8H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	168	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043694 (CHEMBL3355989) Show SMILES Clc1cccc(c1)-c1cnn2ccc(NCC3CCOCC3)nc12 Show InChI InChI=1S/C18H19ClN4O/c19-15-3-1-2-14(10-15)16-12-21-23-7-4-17(22-18(16)23)20-11-13-5-8-24-9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,20,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043689 (CHEMBL3355545 | US10047093, 8-48 | US10392392, Exa...) Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.1,wD:5.8,(2.94,-11.92,;3.72,-13.26,;2.22,-13.65,;5.06,-12.49,;6.38,-13.26,;6.38,-14.81,;5.06,-15.57,;3.72,-14.8,;7.72,-15.57,;9.05,-14.8,;9.05,-13.26,;10.38,-12.49,;11.71,-13.26,;13.17,-12.79,;14.08,-14.03,;13.17,-15.28,;13.93,-16.61,;13.14,-17.94,;13.9,-19.28,;15.44,-19.29,;16.22,-17.96,;17.76,-17.97,;18.52,-19.3,;20.06,-19.31,;17.74,-20.63,;19.2,-20.68,;15.46,-16.62,;11.71,-14.8,;10.38,-15.56,)| Show InChI InChI=1S/C20H21F3N4O2/c1-19(28)8-5-14(6-9-19)25-17-7-10-27-18(26-17)16(12-24-27)13-3-2-4-15(11-13)29-20(21,22)23/h2-4,7,10-12,14,28H,5-6,8-9H2,1H3,(H,25,26)/t14-,19-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043688 (CHEMBL3355546 | US10047093, 8-47 | US10392392, Exa...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:4.3,wD:7.10,(20.54,-14.89,;21.32,-13.57,;19.78,-13.56,;21.32,-12.03,;22.65,-14.35,;23.99,-13.58,;25.31,-14.35,;25.31,-15.89,;23.98,-16.66,;22.65,-15.89,;26.65,-16.66,;27.98,-15.89,;27.98,-14.35,;29.31,-13.57,;30.63,-14.35,;32.1,-13.87,;33.01,-15.12,;32.1,-16.37,;32.86,-17.7,;32.07,-19.02,;32.82,-20.36,;34.37,-20.38,;35.15,-19.04,;36.69,-19.05,;37.45,-20.39,;38.99,-20.4,;36.67,-21.72,;38.13,-21.77,;34.39,-17.71,;30.63,-15.89,;29.31,-16.65,)| Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-29-20(28-19)18(13-26-29)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	204	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437024 (CHEMBL2403058) Show SMILES COc1cc(Nc2ncc(Cl)c(n2)-c2cc(Cl)cc(c2)C#N)ccc1N1CCN(C)CC1 Show InChI InChI=1S/C23H22Cl2N6O/c1-30-5-7-31(8-6-30)20-4-3-18(12-21(20)32-2)28-23-27-14-19(25)22(29-23)16-9-15(13-26)10-17(24)11-16/h3-4,9-12,14H,5-8H2,1-2H3,(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043697 (CHEMBL3355987 | US10047093, 8-63 | US10392392, Exa...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:4.3,wD:7.10,(.73,-52.37,;1.51,-51.04,;-.05,-51.03,;1.52,-49.51,;2.84,-51.82,;4.18,-51.06,;5.51,-51.82,;5.5,-53.37,;4.18,-54.14,;2.84,-53.36,;6.84,-54.14,;8.17,-53.37,;8.17,-51.83,;9.5,-51.05,;10.83,-51.83,;12.29,-51.35,;13.2,-52.6,;12.29,-53.84,;13.05,-55.17,;12.26,-56.5,;13.02,-57.84,;14.56,-57.86,;15.34,-56.52,;16.88,-56.53,;14.58,-55.19,;10.83,-53.37,;9.5,-54.13,)| Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-26-20(25-19)18(13-23-26)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	228	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043701 (CHEMBL3355559 | US10047093, 8-61 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:1.0,wD:4.7,(34.05,-42.38,;35.38,-43.15,;36.72,-42.39,;38.04,-43.16,;38.04,-44.7,;36.71,-45.47,;35.38,-44.69,;39.38,-45.47,;40.71,-44.7,;40.71,-43.16,;42.04,-42.38,;43.37,-43.16,;44.83,-42.68,;45.74,-43.93,;44.83,-45.18,;45.59,-46.51,;44.8,-47.83,;45.56,-49.17,;47.1,-49.19,;47.88,-47.85,;49.42,-47.86,;47.12,-46.52,;43.37,-44.7,;42.04,-45.46,)| Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-23-9-8-17(22-18(16)23)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	237	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043690 (CHEMBL3355544 | US10047093, 8-46 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(50.22,-3.1,;51.55,-3.88,;52.88,-3.11,;54.21,-3.88,;54.21,-5.42,;52.88,-6.19,;51.55,-5.42,;55.54,-6.19,;56.88,-5.42,;56.88,-3.88,;58.21,-3.1,;59.54,-3.88,;61,-3.4,;61.91,-4.65,;61,-5.9,;61.76,-7.23,;60.97,-8.56,;61.73,-9.9,;63.27,-9.91,;64.05,-8.58,;65.59,-8.59,;66.35,-9.93,;67.89,-9.94,;65.57,-11.25,;67.03,-11.3,;63.29,-7.24,;59.54,-5.42,;58.21,-6.18,)| Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-26-9-8-17(25-18(16)26)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50043662 (CHEMBL3355552 | US10047093, 8-56 | US10392392, Exa...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:4.3,wD:7.10,(51,-26.01,;51.77,-24.69,;50.23,-24.68,;51.78,-23.15,;53.11,-25.47,;54.44,-24.7,;55.77,-25.47,;55.77,-27.01,;54.44,-27.78,;53.11,-27.01,;57.1,-27.78,;58.44,-27.01,;58.44,-25.47,;59.76,-24.69,;61.09,-25.47,;62.56,-24.99,;63.46,-26.24,;62.56,-27.49,;63.31,-28.82,;62.53,-30.15,;63.28,-31.49,;64.82,-31.5,;65.61,-30.17,;64.85,-28.83,;67.15,-30.18,;67.91,-31.51,;67.92,-28.85,;68.68,-30.17,;61.09,-27.01,;59.76,-27.77,)| Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-29-20(28-19)18(13-26-29)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	271	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human Flt3 (unknown origin)				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043674 (CHEMBL3355550 | US10047093, 8-54 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:1.0,wD:4.7,(12.63,-23.03,;13.97,-23.8,;15.3,-23.04,;16.63,-23.8,;16.63,-25.35,;15.3,-26.12,;13.97,-25.34,;17.96,-26.12,;19.3,-25.35,;19.3,-23.81,;20.63,-23.03,;21.95,-23.81,;23.42,-23.33,;24.33,-24.58,;23.42,-25.83,;24.18,-27.16,;23.39,-28.48,;24.15,-29.82,;25.69,-29.84,;26.47,-28.5,;25.71,-27.17,;28.01,-28.51,;28.77,-29.85,;28.79,-27.18,;29.55,-28.51,;21.95,-25.35,;20.63,-26.11,)| Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-26-9-8-17(25-18(16)26)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437035 (CHEMBL2403070) Show SMILES CCOC(=O)c1cc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)CC1 Show InChI InChI=1S/C26H27ClN6O2/c1-3-35-25(34)21-16-20(7-8-23(21)33-13-11-32(2)12-14-33)30-26-29-17-22(27)24(31-26)19-6-4-5-18(15-19)9-10-28/h4-8,15-17H,3,9,11-14H2,1-2H3,(H,29,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	289	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043687 (CHEMBL3355547 | US9416132, 8-49) Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:2.1,wD:5.8,(37.44,-13.65,;38.78,-12.89,;40.11,-13.66,;41.44,-12.9,;42.77,-13.66,;42.77,-15.21,;41.44,-15.98,;40.11,-15.2,;44.1,-15.98,;45.44,-15.21,;45.44,-13.67,;46.77,-12.89,;48.09,-13.67,;49.56,-13.19,;50.47,-14.44,;49.56,-15.68,;50.32,-17.02,;49.53,-18.34,;50.29,-19.68,;51.83,-19.7,;52.61,-18.36,;54.15,-18.37,;54.91,-19.71,;56.45,-19.72,;54.13,-21.04,;55.59,-21.08,;51.85,-17.03,;48.09,-15.21,;46.77,-15.97,)| Show InChI InChI=1S/C20H21F3N4O2/c1-28-15-7-5-14(6-8-15)25-18-9-10-27-19(26-18)17(12-24-27)13-3-2-4-16(11-13)29-20(21,22)23/h2-4,9-12,14-15H,5-8H2,1H3,(H,25,26)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	378	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043700 (CHEMBL3355560 | US10047093, 8-62 | US10392392, Exa...) Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:1.1,wD:5.8,(53.53,-42.61,;54.31,-43.95,;52.81,-44.35,;55.65,-43.19,;56.98,-43.96,;56.97,-45.5,;55.65,-46.27,;54.31,-45.5,;58.31,-46.27,;59.64,-45.5,;59.64,-43.96,;60.97,-43.18,;62.3,-43.96,;63.76,-43.48,;64.67,-44.73,;63.76,-45.98,;64.52,-47.31,;63.73,-48.63,;64.49,-49.97,;66.03,-49.99,;66.81,-48.65,;68.35,-48.66,;66.05,-47.32,;62.3,-45.5,;60.97,-46.26,)| Show InChI InChI=1S/C19H21ClN4O/c1-19(25)8-5-15(6-9-19)22-17-7-10-24-18(23-17)16(12-21-24)13-3-2-4-14(20)11-13/h2-4,7,10-12,15,25H,5-6,8-9H2,1H3,(H,22,23)/t15-,19-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	378	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437023 (CHEMBL2403059) Show SMILES COc1cc(cc(c1)-c1nc(Nc2ccc(N3CCN(C)CC3)c(OC)c2)ncc1Cl)C#N Show InChI InChI=1S/C24H25ClN6O2/c1-30-6-8-31(9-7-30)21-5-4-18(13-22(21)33-3)28-24-27-15-20(25)23(29-24)17-10-16(14-26)11-19(12-17)32-2/h4-5,10-13,15H,6-9H2,1-3H3,(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	487	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043701 (CHEMBL3355559 | US10047093, 8-61 | US10392392, Exa...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:1.0,wD:4.7,(34.05,-42.38,;35.38,-43.15,;36.72,-42.39,;38.04,-43.16,;38.04,-44.7,;36.71,-45.47,;35.38,-44.69,;39.38,-45.47,;40.71,-44.7,;40.71,-43.16,;42.04,-42.38,;43.37,-43.16,;44.83,-42.68,;45.74,-43.93,;44.83,-45.18,;45.59,-46.51,;44.8,-47.83,;45.56,-49.17,;47.1,-49.19,;47.88,-47.85,;49.42,-47.86,;47.12,-46.52,;43.37,-44.7,;42.04,-45.46,)| Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-23-9-8-17(22-18(16)23)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	506	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043662 (CHEMBL3355552 | US10047093, 8-56 | US10392392, Exa...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:4.3,wD:7.10,(51,-26.01,;51.77,-24.69,;50.23,-24.68,;51.78,-23.15,;53.11,-25.47,;54.44,-24.7,;55.77,-25.47,;55.77,-27.01,;54.44,-27.78,;53.11,-27.01,;57.1,-27.78,;58.44,-27.01,;58.44,-25.47,;59.76,-24.69,;61.09,-25.47,;62.56,-24.99,;63.46,-26.24,;62.56,-27.49,;63.31,-28.82,;62.53,-30.15,;63.28,-31.49,;64.82,-31.5,;65.61,-30.17,;64.85,-28.83,;67.15,-30.18,;67.91,-31.51,;67.92,-28.85,;68.68,-30.17,;61.09,-27.01,;59.76,-27.77,)| Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-29-20(28-19)18(13-26-29)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	525	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437040 (CHEMBL2403065) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)cc1F Show InChI InChI=1S/C23H22ClFN6/c1-30-9-11-31(12-10-30)21-6-5-18(14-20(21)25)28-23-27-15-19(24)22(29-23)17-4-2-3-16(13-17)7-8-26/h2-6,13-15H,7,9-12H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	548	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043696 (CHEMBL3355991) Show SMILES Clc1cccc(c1)-c1cnn2ccc(nc12)N1CCC(=O)CC1 Show InChI InChI=1S/C17H15ClN4O/c18-13-3-1-2-12(10-13)15-11-19-22-9-6-16(20-17(15)22)21-7-4-14(23)5-8-21/h1-3,6,9-11H,4-5,7-8H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	564	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043686 (CHEMBL3355548) Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnn2ccc(NCC3CCOCC3)nc12 Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-14(10-15)16-12-24-26-7-4-17(25-18(16)26)23-11-13-5-8-27-9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	633	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437030 (CHEMBL2403075) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)cc1-c1ncc(C)o1 Show InChI InChI=1S/C27H26ClN7O/c1-18-16-30-26(36-18)22-15-21(6-7-24(22)35-12-10-34(2)11-13-35)32-27-31-17-23(28)25(33-27)20-5-3-4-19(14-20)8-9-29/h3-7,14-17H,8,10-13H2,1-2H3,(H,31,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	636	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50043663 (CHEMBL3355551 | US10392392, Example 8-55 | US10875...) Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:1.1,wD:5.8,(32.77,-22.86,;33.55,-24.2,;32.05,-24.6,;34.89,-23.44,;36.21,-24.2,;36.21,-25.75,;34.89,-26.52,;33.55,-25.74,;37.55,-26.52,;38.88,-25.75,;38.88,-24.21,;40.21,-23.43,;41.54,-24.21,;43,-23.73,;43.91,-24.98,;43,-26.22,;43.76,-27.56,;42.97,-28.88,;43.73,-30.22,;45.27,-30.24,;46.05,-28.9,;45.29,-27.57,;47.59,-28.91,;48.35,-30.25,;48.37,-27.58,;49.13,-28.91,;41.54,-25.75,;40.21,-26.51,)| Show InChI InChI=1S/C20H21F3N4O/c1-19(28)8-5-15(6-9-19)25-17-7-10-27-18(26-17)16(12-24-27)13-3-2-4-14(11-13)20(21,22)23/h2-4,7,10-12,15,28H,5-6,8-9H2,1H3,(H,25,26)/t15-,19-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	639	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50437039 (CHEMBL2403066) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)cc1O Show InChI InChI=1S/C23H23ClN6O/c1-29-9-11-30(12-10-29)20-6-5-18(14-21(20)31)27-23-26-15-19(24)22(28-23)17-4-2-3-16(13-17)7-8-25/h2-6,13-15,31H,7,9-12H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	674	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B
					More data for this Ligand-Target Pair

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