| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk2 |
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| Ligand | BDBM50443628 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1445193 (CHEMBL3375445) |
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| IC50 | 128±n/a nM |
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| Citation |  Halland, N; Schmidt, F; Weiss, T; Saas, J; Li, Z; Czech, J; Dreyer, M; Hofmeister, A; Mertsch, K; Dietz, U; Strübing, C; Nazare, M Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett6:73-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Sgk2 |
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| Name: | Serine/threonine-protein kinase Sgk2 |
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| Synonyms: | SGK2 | SGK2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47609.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1445193 |
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| Residue: | 427 |
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| Sequence: | MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYR
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
DDDILDC
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| BDBM50443628 |
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| n/a |
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| Name | BDBM50443628 |
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| Synonyms: | CHEMBL3092468 | US9174993, 35 | US9221828, 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClFN6O2S |
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| Mol. Mass. | 418.833 |
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| SMILES | Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |
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| Structure | 
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