| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
|---|
| Ligand | BDBM50446283 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1457063 (CHEMBL3369184) |
|---|
| EC50 | 9.0±n/a nM |
|---|
| Citation |  Fauber, BP; Magnuson, S Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-¿ (ROR¿ or RORc). J Med Chem57:5871-92 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma |
|---|
| Name: | Nuclear receptor ROR-gamma |
|---|
| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58133.31 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_103664 |
|---|
| Residue: | 516 |
|---|
| Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
|
|
|
|---|
| BDBM50446283 |
|---|
| n/a |
|---|
| Name | BDBM50446283 |
|---|
| Synonyms: | CHEMBL3109235 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H24Cl2N2O3S |
|---|
| Mol. Mass. | 515.451 |
|---|
| SMILES | CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(Cl)cc4Cl)ccc3c2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
