Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Transcription factor Jun | ||
Ligand | BDBM50279699 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1458002 (CHEMBL3367176) | ||
IC50 | 5500±n/a nM | ||
Citation | Ye, N; Ding, Y; Wild, C; Shen, Q; Zhou, J Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem57:6930-48 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Transcription factor Jun | |||
Name: | Transcription factor Jun | ||
Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 | ||
Type: | n/a | ||
Mol. Mass.: | 35683.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P05412 | ||
Residue: | 331 | ||
Sequence: |
| ||
BDBM50279699 | |||
n/a | |||
Name | BDBM50279699 | ||
Synonyms: | 2-(4-Methyl-2-phenylamino-thiazol-5-yl)-3-o-tolyl-3H-quinazolin-4-one | CHEMBL474718 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H20N4OS | ||
Mol. Mass. | 424.517 | ||
SMILES | Cc1nc(Nc2ccccc2)sc1-c1nc2ccccc2c(=O)n1-c1ccccc1C |(-4.16,-12.94,;-3.02,-11.9,;-1.51,-12.22,;-.75,-10.89,;.79,-10.88,;1.56,-12.21,;.79,-13.55,;1.57,-14.87,;3.11,-14.87,;3.87,-13.52,;3.09,-12.2,;-1.78,-9.74,;-3.18,-10.37,;-4.51,-9.6,;-5.86,-10.38,;-7.2,-9.61,;-8.54,-10.38,;-9.87,-9.61,;-9.87,-8.06,;-8.54,-7.29,;-7.21,-8.06,;-5.87,-7.27,;-5.88,-5.73,;-4.52,-8.05,;-3.19,-7.27,;-1.86,-8.04,;-.52,-7.27,;-.53,-5.73,;-1.87,-4.96,;-3.2,-5.74,;-4.54,-4.98,)| | ||
Structure |