| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Ligand | BDBM10995 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1448362 (CHEMBL3376281) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  O'Brien, NJ; Brzozowski, M; Wilson, DJ; Deady, LW; Abbott, BM Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors. Bioorg Med Chem22:3781-90 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Name: | 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 63157.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15530 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
EVWRQRYQSHPDAAVQ
|
|
|
|---|
| BDBM10995 |
|---|
| n/a |
|---|
| Name | BDBM10995 |
|---|
| Synonyms: | (1R)-N-methyl-2,3-dihydro-1H-inden-1-amine | N-methyl-1(R)-aminoindan | R-MAI | rasagiline analog |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H13N |
|---|
| Mol. Mass. | 147.2169 |
|---|
| SMILES | CN[C@@H]1CCc2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
