BindingDB PrimarySearch

Found 24 hits with Last Name = 'abbott' and Initial = 'bm'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Substance-P receptor (Homo sapiens (Human))	BDBM50105595 ((R,S)-3-Cyano-naphthalene-1-carboxylic acid {2-(3,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 307-15 (2001) BindingDB Entry DOI: 10.7270/Q2H130JX
AstraZeneca Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50105595 ((R,S)-3-Cyano-naphthalene-1-carboxylic acid {2-(3,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.610	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 307-15 (2001) BindingDB Entry DOI: 10.7270/Q2H130JX
AstraZeneca Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM10995 ((1R)-N-methyl-2,3-dihydro-1H-inden-1-amine \| N-met...) Show SMILES CN[C@@H]1CCc2ccccc12 \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
La Trobe University Curated by ChEMBL					Assay Description Inhibition of PDK1 (unknown origin) expressed in HEK293 cells using PDKtide as substrate after 10 mins by liquid scintillation counting in presence o...				Bioorg Med Chem 22: 3879-86 (2014) Article DOI: 10.1016/j.bmc.2014.06.018 BindingDB Entry DOI: 10.7270/Q2DR2X53
La Trobe University Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM10995 ((1R)-N-methyl-2,3-dihydro-1H-inden-1-amine \| N-met...) Show SMILES CN[C@@H]1CCc2ccccc12 \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
La Trobe University Curated by ChEMBL					Assay Description Inhibition of PDK1 (unknown origin) using PDKtide substrate and [gamma-32P]ATP by scintillation counting method				Bioorg Med Chem 22: 3781-90 (2014) Article DOI: 10.1016/j.bmc.2014.04.037 BindingDB Entry DOI: 10.7270/Q2DB83HS
La Trobe University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Inhibition of human platelet phosphodiesterase 3				Bioorg Med Chem Lett 14: 2847-51 (2004) Article DOI: 10.1016/j.bmcl.2004.03.043 BindingDB Entry DOI: 10.7270/Q2H70F8N
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM50049555 (CHEMBL3311455) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
La Trobe University Curated by ChEMBL					Assay Description Inhibition of PDK1 (unknown origin) expressed in HEK293 cells using PDKtide as substrate after 10 mins by liquid scintillation counting in presence o...				Bioorg Med Chem 22: 3879-86 (2014) Article DOI: 10.1016/j.bmc.2014.06.018 BindingDB Entry DOI: 10.7270/Q2DR2X53
La Trobe University Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM50049556 (CHEMBL3311451) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
La Trobe University Curated by ChEMBL					Assay Description Inhibition of PDK1 (unknown origin) expressed in HEK293 cells using PDKtide as substrate after 10 mins by liquid scintillation counting in presence o...				Bioorg Med Chem 22: 3879-86 (2014) Article DOI: 10.1016/j.bmc.2014.06.018 BindingDB Entry DOI: 10.7270/Q2DR2X53
La Trobe University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50034908 ((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol \| (2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Inhibition of human platelet phosphodiesterase 2				Bioorg Med Chem Lett 14: 2847-51 (2004) Article DOI: 10.1016/j.bmcl.2004.03.043 BindingDB Entry DOI: 10.7270/Q2H70F8N
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50146422 (2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one \| 2...) Show SMILES O=c1cc(oc2c(cccc12)C#Cc1ccccc1)N1CCOCC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Inhibition of human platelet phosphodiesterase 2				Bioorg Med Chem Lett 14: 2847-51 (2004) Article DOI: 10.1016/j.bmcl.2004.03.043 BindingDB Entry DOI: 10.7270/Q2H70F8N
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50146421 (8-(3-Chloro-phenyl)-6-methoxy-2-morpholin-4-yl-chr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Inhibition of human platelet phosphodiesterase 2				Bioorg Med Chem Lett 14: 2847-51 (2004) Article DOI: 10.1016/j.bmcl.2004.03.043 BindingDB Entry DOI: 10.7270/Q2H70F8N
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM12915 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one \|...) Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Inhibition of human platelet phosphodiesterase 2				Bioorg Med Chem Lett 14: 2847-51 (2004) Article DOI: 10.1016/j.bmcl.2004.03.043 BindingDB Entry DOI: 10.7270/Q2H70F8N
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM12915 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one \|...) Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Inhibition of human platelet phosphodiesterase 3				Bioorg Med Chem Lett 14: 2847-51 (2004) Article DOI: 10.1016/j.bmcl.2004.03.043 BindingDB Entry DOI: 10.7270/Q2H70F8N
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576685 (CHEMBL4871128) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Escherichia coli DsbA using DOTA/Eu(III)-CQQGFDGTQNSCK-MCA as substrate in presence of oxidized glutathione measured by fluorescence an...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576681 (CHEMBL4846499) Show SMILES OC(=O)Cc1coc2cc(ccc12)-c1cccc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576682 (CHEMBL4855609) Show SMILES COc1ccc(cc1)-c1ccc2c(CC(O)=O)coc2c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.60E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576683 (CHEMBL4854940) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.03E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576684 (CHEMBL4848780) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	5.31E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576685 (CHEMBL4871128) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	2.74E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576686 (CHEMBL4875684) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	9.78E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576679 (CHEMBL4851994) Show SMILES OC(=O)Cc1coc2ccc(cc12)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	8.20E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576678 (CHEMBL4852788) Show SMILES OC(=O)Cc1coc2cc(ccc12)-c1cccc(c1)C#N Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.30E+6	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576677 (CHEMBL4877192) Show SMILES COc1cccc(c1)-c1ccc2c(CC(O)=O)coc2c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.10E+6	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576676 (CHEMBL4868312) Show SMILES OC(=O)Cc1coc2cc(ccc12)-c1cccc(O)c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	8.30E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair
Thiol:disulfide interchange protein DsbA (Escherichia coli (strain K12))	BDBM50576680 (CHEMBL4860222) Show SMILES OC(=O)Cc1coc2cc(ccc12)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.14E+6	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 15N-labelled Escherichia coli DsbA measured by 1H-15N HSQC NMR spectroscopy				Citation and Details Article DOI: 10.1016/j.bmc.2021.116315 BindingDB Entry DOI: 10.7270/Q2765K51
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)