| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50105595 |
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| Substrate/Competitor | n/a |
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| Ki | 0.61±n/a nM |
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| Comments | PDSP_2010 |
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| Citation |  Rumsey, WL; Aharony, D; Bialecki, RA; Abbott, BM; Barthlow, HG; Caccese, R; Ghanekar, S; Lengel, D; McCarthy, M; Wenrich, B; Undem, B; Ohnmacht, C; Shenvi, A; Albert, JS; Brown, F; Bernstein, PR; Russell, K Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors. J Pharmacol Exp Ther298:307-15 (2001) [PubMed] |
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| More Info.: | Get all data from this article |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50105595 |
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| n/a |
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| Name | BDBM50105595 |
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| Synonyms: | (R,S)-3-Cyano-naphthalene-1-carboxylic acid {2-(3,4-dichloro-phenyl)-4-[4-(2-methanesulfinyl-phenyl)-piperidin-1-yl]-butyl}-methyl-amide | 3-Cyano-naphthalene-1-carboxylic acid {(S)-2-(3,4-dichloro-phenyl)-4-[4-(2-methanesulfinyl-phenyl)-piperidin-1-yl]-butyl}-methyl-amide | CHEMBL319821 | ZD6021 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H35Cl2N3O2S |
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| Mol. Mass. | 632.642 |
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| SMILES | CN(C[C@@H](CCN1CCC(CC1)c1ccccc1S(C)=O)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(cc2ccccc12)C#N |
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| Structure | 
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