BindingDB PrimarySearch

Found 21 hits Enz. Inhib. hit(s) with Target = 'cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B' and Ligand = 'BDBM15296'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Inhibition of human phosphodiesterase 3				J Med Chem 48: 3449-62 (2005) Article DOI: 10.1021/jm040217u BindingDB Entry DOI: 10.7270/Q21G0N2H
Monash University (Parkville Campus) Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Genova Curated by ChEMBL					Assay Description Inhibition of human platelet PDE3				J Med Chem 50: 2886-95 (2007) Article DOI: 10.1021/jm0611511 BindingDB Entry DOI: 10.7270/Q24F1TGX
Universit£ di Genova Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle				J Med Chem 36: 1387-92 (1993) BindingDB Entry DOI: 10.7270/Q2JW8FHP
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Sterling Winthrop Pharmaceuticals Research Division Curated by ChEMBL					Assay Description In vitro inhibitory activity against cAMP phosphodiesterase III in dog aorta				J Med Chem 37: 248-54 (1994) Article DOI: 10.1021/jm00028a007 BindingDB Entry DOI: 10.7270/Q2X069RV
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Sterling Winthrop Pharmaceuticals Research Division Curated by ChEMBL					Assay Description Inhibition of cAMP Phosphodiesterase 3				J Med Chem 35: 4858-65 (1992) BindingDB Entry DOI: 10.7270/Q2H13480
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Inhibition of human platelet phosphodiesterase 3				Bioorg Med Chem Lett 14: 2847-51 (2004) Article DOI: 10.1016/j.bmcl.2004.03.043 BindingDB Entry DOI: 10.7270/Q2H70F8N
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Scienze Farmaceutiche, Firenze, Italy. Curated by ChEMBL					Assay Description Inhibition of guinea pig ventricular Phosphodiesterase 3				J Med Chem 40: 1417-21 (1997) Article DOI: 10.1021/jm970105l BindingDB Entry DOI: 10.7270/Q2RX9FSV
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from guinea pig ventricular tissue				J Med Chem 41: 4021-35 (1998) Article DOI: 10.1021/jm981012m BindingDB Entry DOI: 10.7270/Q2TM7DV3
Rhône-Poulenc Rorer Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibition of cyclic AMP phosphodiesterase from human platelets				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of platelet cAMP phosphodiesterase				J Med Chem 31: 2136-45 (1988) BindingDB Entry DOI: 10.7270/Q2VX0JQQ
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M				J Med Chem 32: 342-50 (1989) BindingDB Entry DOI: 10.7270/Q27083P1
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mitsui Toatsu Chemicals Inc. Curated by ChEMBL					Assay Description Inhibition of canine Phosphodiesterase III (PDE 3)				J Med Chem 32: 351-7 (1989) BindingDB Entry DOI: 10.7270/Q2377BZ9
Mitsui Toatsu Chemicals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of cAMP-phosphodiesterase PDE 3 from guinea pig, range 1.9-3.1				J Med Chem 30: 1023-9 (1987) BindingDB Entry DOI: 10.7270/Q2862FF4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of fraction III of guinea pig phosphodiesterase				J Med Chem 27: 1099-101 (1984) BindingDB Entry DOI: 10.7270/Q26Q1W70
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cAMP PDE III enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	22
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH US Patent					Assay Description PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...				US Patent US9242982 (2016) BindingDB Entry DOI: 10.7270/Q2BV7FF6
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH US Patent					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indian Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of PDE3 by Biomol Green quantizyme assay system				Bioorg Med Chem Lett 22: 6010-5 (2012) Article DOI: 10.1016/j.bmcl.2012.05.019 BindingDB Entry DOI: 10.7270/Q2P84FRB
Indian Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	22
Council of Scientific & Industrial Research US Patent					Assay Description PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...				US Patent US9249139 (2016) BindingDB Entry DOI: 10.7270/Q27W6B1M
Council of Scientific & Industrial Research US Patent					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of cardiac phosphodiesterase-3 isolated from canine heart.				J Med Chem 33: 380-6 (1990) BindingDB Entry DOI: 10.7270/Q241708F
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Cardiotonic effect by inhibition of cAMP phosphodiesterase (PDE III)				J Med Chem 29: 635-40 (1986) BindingDB Entry DOI: 10.7270/Q2T72KNS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair