| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Ligand | BDBM50046816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452802 (CHEMBL3365144) |
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| IC50 | 95000±n/a nM |
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| Citation |  Perdih, A; Hrast, M; Barreteau, H; Gobec, S; Wolber, G; Solmajer, T Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF). Bioorg Med Chem22:4124-34 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Synonyms: | D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD |
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| Type: | Ligase |
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| Mol. Mass.: | 46963.02 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | n/a |
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| Residue: | 438 |
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| Sequence: | MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLND
EWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVT
TLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNV
TEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL
NHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGL
PHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYL
NGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQF
KNFEQRGNEFARLAKELG
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| BDBM50046816 |
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| n/a |
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| Name | BDBM50046816 |
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| Synonyms: | CHEMBL3310459 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N2O5S2 |
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| Mol. Mass. | 402.444 |
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| SMILES | Cc1cc(\C=C2\SC(=S)NC2=O)c(C)n1-c1cc(cc(c1)C(O)=O)C(O)=O |
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| Structure | 
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