Reaction Details |
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Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
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Ligand | BDBM50047362 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1458227 (CHEMBL3368725) |
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IC50 | 3000±n/a nM |
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Citation | Vuorinen, A; Engeli, R; Meyer, A; Bachmann, F; Griesser, UJ; Schuster, D; Odermatt, A Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17ß-hydroxysteroid dehydrogenase 2 inhibitors. J Med Chem57:5995-6007 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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17-beta-hydroxysteroid dehydrogenase type 2 |
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Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
Type: | Oxidoreductase; single-pass type II membrane protein |
Mol. Mass.: | 42795.29 |
Organism: | Homo sapiens (Human) |
Description: | Enzyme was partially purified from human placenta. |
Residue: | 387 |
Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
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BDBM50047362 |
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n/a |
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Name | BDBM50047362 |
Synonyms: | CHEMBL3314616 |
Type | Small organic molecule |
Emp. Form. | C12H9ClFNO3S |
Mol. Mass. | 301.721 |
SMILES | Oc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1Cl |
Structure |
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