Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetUrotensin II receptor
LigandBDBM50048690
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1451066
Ki 6.5±n/a nM
Citation Carotenuto AAuriemma LMerlino FYousif AMMarasco DLimatola ACampiglia PGomez-Monterrey ISanticioli PMeini SMaggi CANovellino EGrieco P Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J Med Chem 57:5965-74 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urotensin II receptor
Name:Urotensin II receptor
Synonyms:G-protein coupled receptor 14 | UR-II-R | Urotensin-II
Type:Enzyme Catalytic Domain
Mol. Mass.:42159.71
Organism:Homo sapiens (Human)
Description:Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50048690
n/a
NameBDBM50048690
Synonyms:CHEMBL3315143
TypeSmall organic molecule
Emp. Form.C55H68N10O11S2
Mol. Mass.1109.319
SMILESCC(C)[C@H](NC(=O)[C@@H]1CSSC(C)(C)[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2cccc3ccccc23)C(=O)N1)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: