| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 3 |
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| Ligand | BDBM50426570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1457493 (CHEMBL3367860) |
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| IC50 | 300±n/a nM |
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| Citation |  Flaherty, DP; Simpson, DS; Miller, M; Maki, BE; Zou, B; Shi, J; Wu, M; McManus, OB; Aubé, J; Li, M; Golden, JE Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett24:3968-73 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 3 |
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| Name: | Potassium channel subfamily K member 3 |
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| Synonyms: | Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1 |
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| Type: | Protein |
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| Mol. Mass.: | 43534.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14649 |
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| Residue: | 394 |
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| Sequence: | MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYE
ELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPL
TLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSH
YEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLN
LVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
AEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRR
CLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
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| BDBM50426570 |
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| n/a |
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| Name | BDBM50426570 |
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| Synonyms: | CHEMBL2324344 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N4O2 |
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| Mol. Mass. | 468.59 |
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| SMILES | CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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