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TargetSodium-dependent proline transporter
LigandBDBM50052718
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1456629 (CHEMBL3370229)
IC50 24±n/a nM
Citation Zipp, GGBarbosa, JGreen, MATerranova, KMFink, CYu, XCNouraldeen, AWilson, ASavelieva, KLanthorn, THDavid Kimball, S Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorg Med Chem Lett24:3886-90 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent proline transporter
Name:Sodium-dependent proline transporter
Synonyms:PROT | SC6A7_HUMAN | SLC6A7 | Sodium-dependent proline transporter | Solute carrier family 6 member 7
Type:PROTEIN
Mol. Mass.:70910.83
Organism:Homo sapiens (Human)
Description:ChEMBL_109456
Residue:636
Sequence:
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV
WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA
AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP
LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG
KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG
VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA
KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR
PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ
RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI
LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS
PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50052718
n/a
NameBDBM50052718
Synonyms:CHEMBL3318574
TypeSmall organic molecule
Emp. Form.C23H23ClN4O
Mol. Mass.406.908
SMILESCC1CN(CC(C)N1C(=O)c1ccc(cc1)-c1cccc(Cl)c1)c1ncccn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: