Reaction Details |
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Target | Sodium-dependent proline transporter |
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Ligand | BDBM50052723 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1456629 (CHEMBL3370229) |
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IC50 | 21±n/a nM |
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Citation | Zipp, GG; Barbosa, J; Green, MA; Terranova, KM; Fink, C; Yu, XC; Nouraldeen, A; Wilson, A; Savelieva, K; Lanthorn, TH; David Kimball, S Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorg Med Chem Lett24:3886-90 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent proline transporter |
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Name: | Sodium-dependent proline transporter |
Synonyms: | PROT | SC6A7_HUMAN | SLC6A7 | Sodium-dependent proline transporter | Solute carrier family 6 member 7 |
Type: | PROTEIN |
Mol. Mass.: | 70910.83 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109456 |
Residue: | 636 |
Sequence: | MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV
WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA
AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP
LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG
KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG
VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA
KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR
PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ
RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI
LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS
PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
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BDBM50052723 |
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n/a |
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Name | BDBM50052723 |
Synonyms: | CHEMBL3318579 |
Type | Small organic molecule |
Emp. Form. | C22H21ClN4O |
Mol. Mass. | 392.881 |
SMILES | C[C@H]1CN(CCN1C(=O)c1ccc(cc1)-c1ccc(Cl)cc1)c1ncccn1 |r| |
Structure |
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