| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50267832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1453161 (CHEMBL3364795) |
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| Ki | 219±n/a nM |
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| Citation |  Medina, RA; Vázquez-Villa, H; Gómez-Tamayo, JC; Benhamú, B; Martín-Fontecha, M; de la Fuente, T; Caltabiano, G; Hedlund, PB; Pardo, L; López-Rodríguez, ML The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo. J Med Chem57:6879-84 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50267832 |
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| n/a |
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| Name | BDBM50267832 |
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| Synonyms: | 1-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)butyl]-1,3-dihydro-2Hindol-2-one | CHEMBL445334 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N2O |
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| Mol. Mass. | 320.4281 |
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| SMILES | O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 |
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| Structure | 
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