| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1 |
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| Ligand | BDBM50056680 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1453218 (CHEMBL3365511) |
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| IC50 | 20±n/a nM |
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| Citation |  Mohedas, AH; Wang, Y; Sanvitale, CE; Canning, P; Choi, S; Xing, X; Bullock, AN; Cuny, GD; Yu, PB Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem57:7900-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1 |
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| Name: | Activin receptor type-1 |
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| Synonyms: | ACVR1_MOUSE | ALK2 | ActR-I | ActRIA | Acvr | Acvr1 | Acvrlk2 | Tgfb1 |
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| Type: | Protein |
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| Mol. Mass.: | 57231.35 |
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| Organism: | Mus musculus |
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| Description: | n/a |
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| Residue: | 509 |
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| Sequence: | MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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| BDBM50056680 |
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| n/a |
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| Name | BDBM50056680 |
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| Synonyms: | CHEMBL3341794 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N5O3 |
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| Mol. Mass. | 445.5136 |
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| SMILES | COc1cc(cc(OC)c1OC)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 |
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| Structure | 
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