| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 8 |
|---|
| Ligand | BDBM62988 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1453239 (CHEMBL3365532) |
|---|
| EC50 | 7300±n/a nM |
|---|
| Citation |  Beesu, M; Malladi, SS; Fox, LM; Jones, CD; Dixit, A; David, SA Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines. J Med Chem57:7325-41 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 8 |
|---|
| Name: | Toll-like receptor 8 |
|---|
| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 119828.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NR97 |
|---|
| Residue: | 1041 |
|---|
| Sequence: | MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
|
|
|
|---|
| BDBM62988 |
|---|
| n/a |
|---|
| Name | BDBM62988 |
|---|
| Synonyms: | (1-butylbenzimidazol-2-yl)amine;hydrochloride | 1-butyl-2-benzimidazolamine;hydrochloride | 1-butylbenzimidazol-2-amine;hydrochloride | MLS000519038 | SMR000129458 | cid_9550888 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H15N3 |
|---|
| Mol. Mass. | 189.2569 |
|---|
| SMILES | CCCCn1c(N)nc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
