Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM50058024 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1451456 (CHEMBL3364305) |
---|
IC50 | 640±n/a nM |
---|
Citation | Kumar, VP; Cisneros, JA; Frey, KM; Castellanos-Gonzalez, A; Wang, Y; Gangjee, A; White, AC; Jorgensen, WL; Anderson, KS Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorg Med Chem Lett24:4158-61 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
BDBM50058024 |
---|
n/a |
---|
Name | BDBM50058024 |
Synonyms: | CHEMBL2426247 |
Type | Small organic molecule |
Emp. Form. | C19H19N5O6 |
Mol. Mass. | 413.3841 |
SMILES | Nc1nc2[nH]cc(Cc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r| |
Structure |
|