| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM50061603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1461782 (CHEMBL3395658) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Wu, B; Wang, HL; Cee, VJ; Lanman, BA; Nixey, T; Pettus, L; Reed, AB; Wurz, RP; Guerrero, N; Sastri, C; Winston, J; Lipford, JR; Lee, MR; Mohr, C; Andrews, KL; Tasker, AS Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorg Med Chem Lett25:775-80 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM50061603 |
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| n/a |
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| Name | BDBM50061603 |
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| Synonyms: | CHEMBL3394167 | US9321756, 157 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N5OS |
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| Mol. Mass. | 351.425 |
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| SMILES | CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1 |
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| Structure | 
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