| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM50061630 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1461784 (CHEMBL3395660) |
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| IC50 | 181±n/a nM |
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| Citation |  Wu, B; Wang, HL; Cee, VJ; Lanman, BA; Nixey, T; Pettus, L; Reed, AB; Wurz, RP; Guerrero, N; Sastri, C; Winston, J; Lipford, JR; Lee, MR; Mohr, C; Andrews, KL; Tasker, AS Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorg Med Chem Lett25:775-80 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM50061630 |
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| n/a |
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| Name | BDBM50061630 |
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| Synonyms: | CHEMBL3394062 | US9321756, 217 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N5S |
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| Mol. Mass. | 357.432 |
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| SMILES | CNc1nnc(s1)-c1ccc2[nH]cc(-c3cnc4ccccc4c3)c2c1 |
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| Structure | 
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