Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-3

Ligand

BDBM50061606

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1461784 (CHEMBL3395660)

IC50

97±n/a nM

Citation

Wu, B; Wang, HL; Cee, VJ; Lanman, BA; Nixey, T; Pettus, L; Reed, AB; Wurz, RP; Guerrero, N; Sastri, C; Winston, J; Lipford, JR; Lee, MR; Mohr, C; Andrews, KL; Tasker, AS Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorg Med Chem Lett25:775-80 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-3

Name:

Serine/threonine-protein kinase pim-3

Synonyms:

PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)

Type:

Protein

Mol. Mass.:

35888.19

Organism:

Homo sapiens (Human)

Description:

Q86V86

Residue:

326

Sequence:

MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL

BDBM50061606

n/a

Name

BDBM50061606

Synonyms:

CHEMBL3394064 | US9321756, 138

Type

Small organic molecule

Emp. Form.

C16H10F2N4S

Mol. Mass.

328.339

SMILES

Nc1nnc(s1)-c1ccc2[nH]cc(-c3c(F)cccc3F)c2c1 |(-7.36,1.9,;-6.13,2.04,;-5.37,3.37,;-3.86,3.05,;-3.71,1.53,;-5.1,.89,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;1.29,3.91,;.07,3.74,;1.86,5.34,;3.38,5.55,;4.33,4.34,;3.76,2.91,;4.52,1.94,;.3,.77,;-1.03,1.55,)|

Structure