| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50064054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1464502 (CHEMBL3405624) |
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| IC50 | 1540±n/a nM |
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| Citation |  Sang, Z; Li, Y; Qiang, X; Xiao, G; Liu, Q; Tan, Z; Deng, Y Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. Bioorg Med Chem23:668-80 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_RAT | Acetylcholinesterase (AChE) | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | Acetylcholinesterase precursor | Acetylcholinesterase, AChE | Ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 68193.62 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P37136 |
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| Residue: | 614 |
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| Sequence: | MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
ISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
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| BDBM50064054 |
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| n/a |
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| Name | BDBM50064054 |
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| Synonyms: | CHEMBL3401001 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23NO7 |
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| Mol. Mass. | 413.4205 |
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| SMILES | CCN(C)C(=O)Oc1ccc(cc1)-c1cc(=O)c2c(OC)c(OC)c(OC)cc2o1 |
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| Structure | 
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