Reaction Details |
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Target | Oxysterols receptor LXR-alpha |
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Ligand | BDBM50064379 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1464816 (CHEMBL3404171) |
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EC50 | 1700±n/a nM |
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Citation | Matsuda, T; Okuda, A; Watanabe, Y; Miura, T; Ozawa, H; Tosaka, A; Yamazaki, K; Yamaguchi, Y; Kurobuchi, S; Koura, M; Shibuya, K Design and discovery of 2-oxochromene derivatives as liver X receptorß-selective agonists. Bioorg Med Chem Lett25:1274-8 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxysterols receptor LXR-alpha |
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Name: | Oxysterols receptor LXR-alpha |
Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50403.85 |
Organism: | Homo sapiens (Human) |
Description: | Q13133 |
Residue: | 447 |
Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM50064379 |
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n/a |
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Name | BDBM50064379 |
Synonyms: | CHEMBL3403691 |
Type | Small organic molecule |
Emp. Form. | C25H31F3N2O5 |
Mol. Mass. | 496.5192 |
SMILES | CCCc1cc2c(cc(=O)oc2c(CCC)c1OCCCCN1C(=O)C(C)N(C)C1=O)C(F)(F)F |
Structure |
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