| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 5 |
|---|
| Ligand | BDBM50066434 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1465792 (CHEMBL3405908) |
|---|
| Ki | 6.8±n/a nM |
|---|
| Citation |  Nógrádi, K; Wágner, G; Domány, G; Bobok, A; Magdó, I; Kolok, S; Mikó-Bakk, ML; Vastag, M; Sághy, K; Gyertyán, I; Kóti, J; Gál, K; Farkas, S; Keseru, GM; Greiner, I; Szombathelyi, Z Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization. Bioorg Med Chem Lett25:1724-9 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 5 |
|---|
| Name: | Metabotropic glutamate receptor 5 |
|---|
| Synonyms: | GRM5_RAT | Gprc1e | Grm5 | Metabotropic glutamate receptor | Mglur5 | metabotropic glutamate 5 | metabotropic glutamate 5/1-C | metabotropic glutamate 5/1-F | metabotropic glutamate 5a |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 131900.14 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P31424 |
|---|
| Residue: | 1203 |
|---|
| Sequence: | MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
EEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSD
KTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGIC
IAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLL
LGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQH
RFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPG
YAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDY
INVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENE
YVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIF
IIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSA
LVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMH
DYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTT
CIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTST
VVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGN
GGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGP
GAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPIST
LSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAA
TPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAE
SAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSS
SSL
|
|
|
|---|
| BDBM50066434 |
|---|
| n/a |
|---|
| Name | BDBM50066434 |
|---|
| Synonyms: | CHEMBL3401588 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H13Cl2NO2S2 |
|---|
| Mol. Mass. | 434.359 |
|---|
| SMILES | Cc1ccc(cc1Cl)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
