Reaction Details | |||
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Target | Metabotropic glutamate receptor 5 | ||
Ligand | BDBM50066735 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1465792 (CHEMBL3405908) | ||
Ki | 1.8±n/a nM | ||
Citation | Nógrádi, K; Wágner, G; Domány, G; Bobok, A; Magdó, I; Kolok, S; Mikó-Bakk, ML; Vastag, M; Sághy, K; Gyertyán, I; Kóti, J; Gál, K; Farkas, S; Keseru, GM; Greiner, I; Szombathelyi, Z Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization. Bioorg Med Chem Lett25:1724-9 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 5 | |||
Name: | Metabotropic glutamate receptor 5 | ||
Synonyms: | GRM5_RAT | Gprc1e | Grm5 | Metabotropic glutamate receptor | Mglur5 | metabotropic glutamate 5 | metabotropic glutamate 5/1-C | metabotropic glutamate 5/1-F | metabotropic glutamate 5a | ||
Type: | Enzyme | ||
Mol. Mass.: | 131900.14 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | P31424 | ||
Residue: | 1203 | ||
Sequence: |
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BDBM50066735 | |||
n/a | |||
Name | BDBM50066735 | ||
Synonyms: | CHEMBL3403121 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H12FN3O2S2 | ||
Mol. Mass. | 409.457 | ||
SMILES | Nc1cnc2sc(c(-c3ccccc3F)c2c1)S(=O)(=O)c1cccc(c1)C#N |(-3.45,-1.38,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.66,.02,;1.76,-1.24,;2.24,-2.7,;1.13,-3.76,;1.5,-5.26,;2.98,-5.69,;4.09,-4.62,;3.72,-3.12,;4.61,-2.27,;.3,-.77,;-1.03,-1.55,;4.2,.04,;4.82,-1.02,;5.43,.05,;4.95,1.38,;4.17,2.7,;4.92,4.05,;6.46,4.06,;7.25,2.74,;6.49,1.4,;8.79,2.75,;10.02,2.77,)| | ||
Structure |