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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 5 | ||
| Ligand | BDBM50066754 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1465792 (CHEMBL3405908) | ||
| Ki | 3.5±n/a nM | ||
| Citation |  Nógrádi, K; Wágner, G; Domány, G; Bobok, A; Magdó, I; Kolok, S; Mikó-Bakk, ML; Vastag, M; Sághy, K; Gyertyán, I; Kóti, J; Gál, K; Farkas, S; Keseru, GM; Greiner, I; Szombathelyi, Z Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization. Bioorg Med Chem Lett25:1724-9 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 5 | |||
| Name: | Metabotropic glutamate receptor 5 | ||
| Synonyms: | GRM5_RAT | Gprc1e | Grm5 | Metabotropic glutamate receptor | Mglur5 | metabotropic glutamate 5 | metabotropic glutamate 5/1-C | metabotropic glutamate 5/1-F | metabotropic glutamate 5a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 131900.14 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | P31424 | ||
| Residue: | 1203 | ||
| Sequence: |
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| BDBM50066754 | |||
| n/a | |||
| Name | BDBM50066754 | ||
| Synonyms: | CHEMBL3403091 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H11ClN2O2S2 | ||
| Mol. Mass. | 410.897 | ||
| SMILES | Clc1ccccc1-c1c(sc2ncccc12)S(=O)(=O)c1cccc(c1)C#N |(4.61,-2.27,;3.72,-3.12,;4.09,-4.62,;2.98,-5.69,;1.5,-5.26,;1.13,-3.76,;2.24,-2.7,;1.76,-1.24,;2.66,.02,;1.76,1.24,;.3,.77,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;4.2,.04,;4.82,-1.02,;5.43,.05,;4.95,1.38,;4.17,2.7,;4.92,4.05,;6.46,4.06,;7.25,2.74,;6.49,1.4,;8.79,2.75,;10.02,2.77,)| | ||
| Structure | 
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