| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM50067460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1465279 (CHEMBL3406498) |
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| Ki | 86±n/a nM |
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| Citation |  Wan, Y; Wu, S; Xiao, G; Liu, T; Hou, X; Chen, C; Guan, P; Yang, X; Fang, H Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. Bioorg Med Chem23:1994-2003 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50067460 |
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| n/a |
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| Name | BDBM50067460 |
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| Synonyms: | CHEMBL3401800 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H22BrN3O6S3 |
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| Mol. Mass. | 708.622 |
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| SMILES | [O-][N+](=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N([C@@H](Cc3ccc(Br)cc3)C(=O)NS(=O)(=O)c3ccccc3)C2=O)cc1 |r| |
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| Structure | 
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