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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Proto-oncogene tyrosine-protein kinase Src | ||
| Ligand | BDBM50067540 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1465694 (CHEMBL3405455) | ||
| Ki | 3100±n/a nM | ||
| Citation |  Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett25:1990-4 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Proto-oncogene tyrosine-protein kinase Src | |||
| Name: | Proto-oncogene tyrosine-protein kinase Src | ||
| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src | ||
| Type: | Protein | ||
| Mol. Mass.: | 59838.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P12931 | ||
| Residue: | 536 | ||
| Sequence: |
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| BDBM50067540 | |||
| n/a | |||
| Name | BDBM50067540 | ||
| Synonyms: | CHEMBL3401990 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21F2N5O2S | ||
| Mol. Mass. | 433.475 | ||
| SMILES | CS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:11.13,wD:4.3,(1.06,4.97,;1.05,3.73,;1.93,3.21,;2.12,4.34,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;2.34,1.32,;2.39,2.86,;3.74,3.59,;5.05,2.78,;5.01,1.24,;3.65,.51,;3.61,-.72,;3.79,5.12,;5.05,5.94,;4.63,7.43,;3.1,7.48,;2.12,8.67,;.58,8.39,;.06,6.95,;-1.15,6.73,;1.06,5.75,;2.58,6.04,)| | ||
| Structure | 
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