Ki Summary

Reaction Details

Report a problem with these data

Target

Tyrosine-protein kinase BTK

Ligand

BDBM50068544

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1466556 (CHEMBL3407013)

8.8±n/a nM

Citation

Asami, T; Kawahata, W; Sawa, M TR-FRET binding assay targeting unactivated form of Bruton's tyrosine kinase. Bioorg Med Chem Lett25:2033-6 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase BTK

Name:

Tyrosine-protein kinase BTK

Synonyms:

Type:

Enzyme

Mol. Mass.:

76289.95

Organism:

Homo sapiens (Human)

Description:

Q06187

Residue:

659

Sequence:

MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES

BDBM50068544

n/a

Name

BDBM50068544

Synonyms:

CHEMBL3402354

Type

Small organic molecule

Emp. Form.

C57H55N7O10S

Mol. Mass.

1030.153

SMILES

Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)NCCOCCOCCNC(=S)Nc2ccc(c(c2)C(O)=O)-c2c3ccc(O)cc3oc3cc(=O)ccc23)n1 |(18.54,-19.68,;17.46,-19.08,;17.44,-17.54,;18.76,-16.75,;18.73,-15.21,;17.66,-14.61,;20.05,-14.41,;20.03,-12.87,;21.35,-12.08,;22.7,-12.83,;22.72,-14.37,;21.4,-15.16,;24.02,-12.04,;24,-10.81,;25.1,-12.64,;25.08,-11.41,;16.09,-16.79,;14.77,-17.58,;14.8,-19.12,;16.14,-19.87,;16.16,-21.41,;17.51,-22.16,;17.53,-23.7,;18.6,-24.31,;16.2,-24.49,;16.22,-25.72,;14.86,-23.74,;13.53,-24.53,;12.19,-23.77,;10.87,-24.56,;9.52,-23.8,;9.51,-22.26,;10.83,-21.48,;12.17,-22.23,;8.17,-21.5,;7.11,-22.13,;8.15,-19.96,;6.81,-19.2,;6.8,-17.66,;5.46,-16.9,;5.44,-15.36,;4.1,-14.6,;4.09,-13.06,;2.75,-12.3,;2.74,-10.76,;1.39,-10,;1.38,-8.46,;2.44,-7.84,;.04,-7.7,;.03,-6.16,;1.35,-5.38,;1.34,-3.84,;0,-3.08,;-1.32,-3.86,;-1.31,-5.4,;-2.66,-3.1,;-2.67,-2.07,;-3.73,-3.73,;,-1.54,;1.31,-.77,;2.67,-1.54,;4,-.77,;4,.77,;5.07,1.39,;2.67,1.54,;1.31,.77,;,1.54,;-1.33,.77,;-2.67,1.54,;-4,.77,;-5.07,1.39,;-4,-.77,;-2.67,-1.54,;-1.33,-.77,;14.84,-22.2,)|

Structure