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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM50068574 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1466556 (CHEMBL3407013) | ||
| Kd | 2.5±n/a nM | ||
| Citation |  Asami, T; Kawahata, W; Sawa, M TR-FRET binding assay targeting unactivated form of Bruton's tyrosine kinase. Bioorg Med Chem Lett25:2033-6 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
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| BDBM50068574 | |||
| n/a | |||
| Name | BDBM50068574 | ||
| Synonyms: | CHEMBL3402355 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C55H49N7O8S | ||
| Mol. Mass. | 968.085 | ||
| SMILES | Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)N2CCN(CC2)C(=S)Nc2ccc(c(c2)C(O)=O)-c2c3ccc(O)cc3oc3cc(=O)ccc23)n1 |(-8.97,-12.95,;-7.9,-12.33,;-7.9,-10.79,;-9.23,-10.02,;-9.23,-8.47,;-8.16,-7.86,;-10.56,-7.7,;-10.56,-6.16,;-11.89,-5.39,;-13.23,-6.16,;-13.23,-7.7,;-11.9,-8.47,;-14.56,-5.38,;-14.56,-4.15,;-15.63,-6,;-15.62,-4.77,;-6.57,-10.02,;-5.23,-10.8,;-5.24,-12.34,;-6.57,-13.1,;-6.57,-14.64,;-7.91,-15.41,;-7.91,-16.95,;-8.97,-17.57,;-6.57,-17.72,;-6.57,-18.96,;-5.24,-16.95,;-3.9,-17.72,;-2.57,-16.95,;-1.23,-17.71,;.1,-16.94,;.09,-15.4,;-1.24,-14.63,;-2.57,-15.41,;1.42,-14.62,;2.49,-15.23,;1.42,-13.08,;2.74,-12.3,;2.73,-10.76,;1.39,-10,;.07,-10.78,;.08,-12.32,;1.38,-8.46,;2.44,-7.84,;.04,-7.7,;.03,-6.16,;1.35,-5.38,;1.34,-3.84,;0,-3.08,;-1.32,-3.86,;-1.31,-5.4,;-2.66,-3.1,;-2.67,-2.07,;-3.73,-3.73,;,-1.54,;1.31,-.77,;2.67,-1.54,;4,-.77,;4,.77,;5.07,1.39,;2.67,1.54,;1.31,.77,;,1.54,;-1.33,.77,;-2.67,1.54,;-4,.77,;-5.07,1.39,;-4,-.77,;-2.67,-1.54,;-1.33,-.77,;-5.24,-15.41,)| | ||
| Structure | 
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