| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hepatocyte growth factor activator |
|---|
| Ligand | BDBM50069122 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1466697 (CHEMBL3404295) |
|---|
| Ki | 22200±n/a nM |
|---|
| Citation |  Franco, FM; Jones, DE; Harris, PK; Han, Z; Wildman, SA; Jarvis, CM; Janetka, JW Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem23:2328-43 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hepatocyte growth factor activator |
|---|
| Name: | Hepatocyte growth factor activator |
|---|
| Synonyms: | HGF activator | HGFA | HGFAC | HGFA_HUMAN | Hepatocyte growth factor activator | Hepatocyte growth factor activator long chain | Hepatocyte growth factor activator short chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 70690.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109514 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILV
TSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLH
ACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQD
PQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGT
RHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVAST
SASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE
YCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHP
WLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIE
KYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGW
GHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGG
PLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
|
|
|
|---|
| BDBM50069122 |
|---|
| n/a |
|---|
| Name | BDBM50069122 |
|---|
| Synonyms: | CHEMBL3402440 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H47N5O3S |
|---|
| Mol. Mass. | 617.844 |
|---|
| SMILES | CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
