| Reaction Details |
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 | Report a problem with these data |
| Target | Scavenger receptor class B member 1 |
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| Ligand | BDBM50069697 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1466967 (CHEMBL3406606) |
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| IC50 | 250±n/a nM |
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| Citation |  Dockendorff, C; Faloon, PW; Pu, J; Yu, M; Johnston, S; Bennion, M; Penman, M; Nieland, TJ; Dandapani, S; Perez, JR; Munoz, B; Palmer, MA; Schreiber, SL; Krieger, M Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett25:2100-5 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Scavenger receptor class B member 1 |
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| Name: | Scavenger receptor class B member 1 |
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| Synonyms: | SCRB1_MOUSE | SR-BI | Scarb1 | Scavenger receptor class B member 1 | Srb1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56761.39 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_103999 |
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| Residue: | 509 |
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| Sequence: | MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIP
VPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLH
FQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEIL
WGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGL
SKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYR
FTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLG
LNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSG
AMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKG
SQDKEAIQAYSESLMSPAAKGTVLQEAKL
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| BDBM50069697 |
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| n/a |
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| Name | BDBM50069697 |
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| Synonyms: | CHEMBL2356172 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35ClN4O6S |
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| Mol. Mass. | 567.097 |
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| SMILES | CC(C)NC(=O)Nc1ccc2O[C@@H](CN(C)S(=O)(=O)c3ccc(Cl)cc3)[C@H](C)CN([C@H](C)CO)C(=O)c2c1 |
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| Structure | 
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