Reaction Details |
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Target | 4-hydroxyphenylpyruvate dioxygenase |
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Ligand | BDBM50072223 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1468440 (CHEMBL3412604) |
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IC50 | 68±n/a nM |
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Citation | Xu, YL; Lin, HY; Ruan, X; Yang, SG; Hao, GF; Yang, WC; Yang, GF Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors. Eur J Med Chem92:427-38 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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4-hydroxyphenylpyruvate dioxygenase |
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Name: | 4-hydroxyphenylpyruvate dioxygenase |
Synonyms: | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD |
Type: | PROTEIN |
Mol. Mass.: | 44937.33 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_123 |
Residue: | 393 |
Sequence: | MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMRE
PWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEM
IDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLR
EKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFG
AGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
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BDBM50072223 |
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n/a |
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Name | BDBM50072223 |
Synonyms: | CHEMBL3408156 |
Type | Small organic molecule |
Emp. Form. | C14H12F3NO5 |
Mol. Mass. | 331.244 |
SMILES | CCC(=O)C(C(C)=O)C(=O)c1ccc(cc1[N+]([O-])=O)C(F)(F)F |
Structure |
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