| Reaction Details |
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 | Report a problem with these data |
| Target | 4-hydroxyphenylpyruvate dioxygenase |
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| Ligand | BDBM50072267 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1468440 (CHEMBL3412604) |
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| IC50 | 150±n/a nM |
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| Citation |  Xu, YL; Lin, HY; Ruan, X; Yang, SG; Hao, GF; Yang, WC; Yang, GF Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors. Eur J Med Chem92:427-38 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 4-hydroxyphenylpyruvate dioxygenase |
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| Name: | 4-hydroxyphenylpyruvate dioxygenase |
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| Synonyms: | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44937.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_123 |
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| Residue: | 393 |
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| Sequence: | MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMRE
PWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEM
IDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLR
EKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFG
AGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
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| BDBM50072267 |
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| n/a |
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| Name | BDBM50072267 |
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| Synonyms: | CHEMBL3408322 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N4O3 |
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| Mol. Mass. | 342.3923 |
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| SMILES | CCn1c2ccc(cc2n(c1=O)C(C)(C)C)C(=O)c1cnn(C)c1O |
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| Structure | 
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