| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional protein GlmU |
|---|
| Ligand | BDBM92472 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1473763 (CHEMBL3418280) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Mehra, R; Sharma, R; Khan, IA; Nargotra, A Identification and optimization of Escherichia coli GlmU inhibitors: an in silico approach with validation thereof. Eur J Med Chem92:78-90 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional protein GlmU |
|---|
| Name: | Bifunctional protein GlmU |
|---|
| Synonyms: | Bifunctional protein (GlmU) | GLMU_ECOLI | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU | yieA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49189.50 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | P0ACC7 |
|---|
| Residue: | 456 |
|---|
| Sequence: | MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGD
LLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDA
KPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADM
KRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQ
SEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKN
SVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSK
AGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGAT
IAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
|
|
|
|---|
| BDBM92472 |
|---|
| n/a |
|---|
| Name | BDBM92472 |
|---|
| Synonyms: | Sulfonamide, 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25N3O7S |
|---|
| Mol. Mass. | 499.536 |
|---|
| SMILES | COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)N(c1ccccc1)c1ccc(N)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
