Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50077887 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1473395 (CHEMBL3419512) |
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Ki | 52±n/a nM |
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Citation | Díaz, JL; Christmann, U; Fernández, A; Torrens, A; Port, A; Pascual, R; Álvarez, I; Burgueño, J; Monroy, X; Montero, A; Balada, A; Vela, JM; Almansa, C Synthesis and structure-activity relationship study of a new series of selectives(1) receptor ligands for the treatment of pain: 4-aminotriazoles. J Med Chem58:2441-51 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50077887 |
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n/a |
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Name | BDBM50077887 |
Synonyms: | CHEMBL3417059 | US9611229, 17 |
Type | Small organic molecule |
Emp. Form. | C16H22FN5 |
Mol. Mass. | 303.3778 |
SMILES | Fc1ccc(Cn2cc(NCCN3CCCCC3)nn2)cc1 |
Structure |
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