| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50316031 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1471054 (CHEMBL3420499) |
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| Ki | 111600±n/a nM |
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| Citation |  Arya, T; Reddi, R; Kishor, C; Ganji, RJ; Bhukya, S; Gumpena, R; McGowan, S; Drag, M; Addlagatta, A Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. J Med Chem58:2350-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43220.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
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| Residue: | 386 |
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| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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| BDBM50316031 |
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| n/a |
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| Name | BDBM50316031 |
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| Synonyms: | CHEMBL1090366 | amino(phenyl)methylphosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C7H10NO3P |
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| Mol. Mass. | 187.133 |
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| SMILES | NC(c1ccccc1)P(O)(O)=O |
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| Structure | 
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