| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM50081198 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1475775 (CHEMBL3425008) |
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| Ki | 22±n/a nM |
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| Citation |  Hoveyda, HR; Fraser, GL; Roy, MO; Dutheuil, G; Batt, F; El Bousmaqui, M; Korac, J; Lenoir, F; Lapin, A; Noël, S; Blanc, S Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I). J Med Chem58:3060-82 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK3R_RAT | Neurokinin 3 receptor | Tac3r | Tacr3 |
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| Type: | n/a |
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| Mol. Mass.: | 51128.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_10983 |
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| Residue: | 452 |
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| Sequence: | MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRAN
LTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDAS
VAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKP
RLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVII
LVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWL
PYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRW
CPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRD
PSANGCSHRGSKSASTTSSFISSPYTSVDEYS
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| BDBM50081198 |
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| n/a |
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| Name | BDBM50081198 |
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| Synonyms: | CHEMBL3422018 | US10065961, Compound 24 | US9475814, 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18N6OS2 |
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| Mol. Mass. | 422.527 |
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| SMILES | C[C@H]1N(CCn2c1nnc2-c1nc(C)ns1)C(=O)c1ccc(cc1)-c1cccs1 |r| |
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| Structure | 
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