| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Ligand | BDBM50081649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1474510 (CHEMBL3423799) |
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| IC50 | 843±n/a nM |
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| Citation |  Chofor, R; Sooriyaarachchi, S; Risseeuw, MD; Bergfors, T; Pouyez, J; Johny, C; Haymond, A; Everaert, A; Dowd, CS; Maes, L; Coenye, T; Alex, A; Couch, RD; Jones, TA; Wouters, J; Mowbray, SL; Van Calenbergh, S Synthesis and bioactivity of฿-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J Med Chem58:2988-3001 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Synonyms: | DXR_MYCTU | dxr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42846.92 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_1474510 |
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| Residue: | 413 |
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| Sequence: | MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
TGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTG
ARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGP
FRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVV
VHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEP
LDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQ
WAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
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| BDBM50081649 |
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| n/a |
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| Name | BDBM50081649 |
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| Synonyms: | CHEMBL3422255 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H21NNaO5P |
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| Mol. Mass. | 337.2838 |
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| SMILES | [Na+].CN(O)C(=O)CC(CCCc1ccccc1)CP(O)([O-])=O |
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| Structure | 
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