| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor IX |
|---|
| Ligand | BDBM50083245 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1474128 (CHEMBL3424102) |
|---|
| Ki | 9000±n/a nM |
|---|
| Citation |  Parker, DL; Walsh, S; Li, B; Kim, E; Sharipour, A; Smith, C; Chen, YH; Berger, R; Harper, B; Zhang, T; Park, M; Shu, M; Wu, J; Xu, J; Dewnani, S; Sherer, EC; Hruza, A; Reichert, P; Geissler, W; Sonatore, L; Ellsworth, K; Balkovec, J; Greenlee, W; Wood, HB Rapid development of two factor IXa inhibitors from hit to lead. Bioorg Med Chem Lett25:2321-5 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor IX |
|---|
| Name: | Coagulation factor IX |
|---|
| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51768.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00740 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
|
|
|
|---|
| BDBM50083245 |
|---|
| n/a |
|---|
| Name | BDBM50083245 |
|---|
| Synonyms: | CHEMBL3423033 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20N6O |
|---|
| Mol. Mass. | 360.4124 |
|---|
| SMILES | Cc1cc2nc(CCNC(=O)c3ccc(cc3)-n3cnnc3)[nH]c2cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
