| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50083245 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1474129 (CHEMBL3424103) |
|---|
| Ki | >62500±n/a nM |
|---|
| Citation |  Parker, DL; Walsh, S; Li, B; Kim, E; Sharipour, A; Smith, C; Chen, YH; Berger, R; Harper, B; Zhang, T; Park, M; Shu, M; Wu, J; Xu, J; Dewnani, S; Sherer, EC; Hruza, A; Reichert, P; Geissler, W; Sonatore, L; Ellsworth, K; Balkovec, J; Greenlee, W; Wood, HB Rapid development of two factor IXa inhibitors from hit to lead. Bioorg Med Chem Lett25:2321-5 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50083245 |
|---|
| n/a |
|---|
| Name | BDBM50083245 |
|---|
| Synonyms: | CHEMBL3423033 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20N6O |
|---|
| Mol. Mass. | 360.4124 |
|---|
| SMILES | Cc1cc2nc(CCNC(=O)c3ccc(cc3)-n3cnnc3)[nH]c2cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
