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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-2 adrenergic receptor | ||
| Ligand | BDBM50084431 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1477238 (CHEMBL3428930) | ||
| EC50 | 0.158489±n/a nM | ||
| Citation |  Hughes, AD; Chen, Y; Hegde, SS; Jasper, JR; Jaw-Tsai, S; Lee, TW; McNamara, A; Pulido-Rios, MT; Steinfeld, T; Mammen, M Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist.. J Med Chem58:2609-22 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Beta-2 adrenergic receptor | |||
| Name: | Beta-2 adrenergic receptor | ||
| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor | ||
| Type: | n/a | ||
| Mol. Mass.: | 46461.69 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07550 | ||
| Residue: | 413 | ||
| Sequence: |
| ||
| BDBM50084431 | |||
| n/a | |||
| Name | BDBM50084431 | ||
| Synonyms: | CHEMBL3426698 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C39H47N5O6 | ||
| Mol. Mass. | 681.8204 | ||
| SMILES | O[C@@H](CNC[C@H]1CC[C@@H](CC1)NC(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1ccc(O)c2[nH]c(=O)ccc12 |r,wU:5.4,wD:1.0,8.11,(.27,-3.7,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4.01,-6.16,;4.01,-7.7,;5.35,-8.47,;5.35,-10.01,;4.01,-10.78,;2.68,-10.01,;2.68,-8.47,;4.01,-12.32,;5.35,-13.09,;6.42,-12.47,;5.35,-14.63,;6.69,-15.4,;6.69,-16.94,;8.03,-17.71,;8.03,-19.25,;6.69,-20.02,;5.36,-19.25,;5.36,-17.71,;6.69,-21.56,;5.35,-22.33,;4.29,-21.71,;5.35,-23.87,;4.02,-24.64,;2.68,-23.86,;1.35,-24.63,;1.34,-26.17,;2.67,-26.94,;4.01,-26.18,;5.34,-26.95,;6.68,-26.19,;8.01,-26.96,;8,-28.5,;6.66,-29.27,;5.33,-28.49,;1.33,-1.54,;2.66,-.77,;2.66,.77,;1.33,1.54,;1.33,2.77,;,.77,;-1.33,1.54,;-2.68,.77,;-3.75,1.39,;-2.68,-.77,;-1.33,-1.54,;,-.77,)| | ||
| Structure | 
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