| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Ligand | BDBM50085599 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1477536 (CHEMBL3430113) |
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| IC50 | 2450±n/a nM |
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| Citation |  Rombouts, FJ; Tresadern, G; Buijnsters, P; Langlois, X; Tovar, F; Steinbrecher, TB; Vanhoof, G; Somers, M; Andrés, JI; Trabanco, AA Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors. ACS Med Chem Lett6:282-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Synonyms: | PDE10_RAT | Pde10a | Phosphodiesterase 10 | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase Type 10 (PDE10A) | Rat recombinant PDE10a (rPDE10a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 90160.88 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | PDE10A was generated from the full-length recombinant rat clone transfected into Sf9 cells. |
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| Residue: | 794 |
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| Sequence: | MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKAD
GFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIG
PFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPAT
SKSTSEKPTRKVDD
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| BDBM50085599 |
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| n/a |
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| Name | BDBM50085599 |
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| Synonyms: | CHEMBL3427725 | US11419874, Example 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13ClF3N5O |
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| Mol. Mass. | 407.777 |
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| SMILES | Cc1nc2ccncc2n2c(nnc12)-c1cc(COCC(F)(F)F)ccc1Cl |
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| Structure | 
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