| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cell division protein FtsZ |
|---|
| Ligand | BDBM50085934 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1477925 (CHEMBL3429346) |
|---|
| IC50 | >128000±n/a nM |
|---|
| Citation |  Nepomuceno, GM; Chan, KM; Huynh, V; Martin, KS; Moore, JT; O'Brien, TE; Pollo, LA; Sarabia, FJ; Tadeus, C; Yao, Z; Anderson, DE; Ames, JB; Shaw, JT Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ. ACS Med Chem Lett6:308-12 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cell division protein FtsZ |
|---|
| Name: | Cell division protein FtsZ |
|---|
| Synonyms: | FTSZ_BACSU | ftsZ |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40385.33 |
|---|
| Organism: | Bacillus subtilis |
|---|
| Description: | ChEMBL_1470470 |
|---|
| Residue: | 382 |
|---|
| Sequence: | MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVNTDAQALNLSKAEVKMQ
IGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVTAGMGGGTGTGAAPVIAQI
AKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDTLIVIPNDRILEIVDKNTPML
EAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIMSNKGSALMGIGIATGENRAAEA
AKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQEAADIVASASDQDVNMIFGSVINE
NLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSIKTHNQSVPKREPKREEPQQQNTVSRH
TSQPADDTLDIPTFLRNRNKRG
|
|
|
|---|
| BDBM50085934 |
|---|
| n/a |
|---|
| Name | BDBM50085934 |
|---|
| Synonyms: | CHEMBL3425686 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24N4 |
|---|
| Mol. Mass. | 356.4635 |
|---|
| SMILES | CN(C)CCNc1nc(nc2ccc(C)cc12)-c1ccc2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
