| Reaction Details |
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 | Report a problem with these data |
| Target | Cell division protein FtsZ |
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| Ligand | BDBM50086201 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1477924 (CHEMBL3429345) |
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| IC50 | 28000±n/a nM |
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| Citation |  Nepomuceno, GM; Chan, KM; Huynh, V; Martin, KS; Moore, JT; O'Brien, TE; Pollo, LA; Sarabia, FJ; Tadeus, C; Yao, Z; Anderson, DE; Ames, JB; Shaw, JT Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ. ACS Med Chem Lett6:308-12 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cell division protein FtsZ |
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| Name: | Cell division protein FtsZ |
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| Synonyms: | FTSZ_ECOLI | ftsZ | sfiB | sulB |
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| Type: | Protein |
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| Mol. Mass.: | 40305.83 |
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| Organism: | Escherichia coli |
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| Description: | P0A9A6 |
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| Residue: | 383 |
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| Sequence: | MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQI
GSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVA
KDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLD
AFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAA
EMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDP
DMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVND
NAPQTAKEPDYLDIPAFLRKQAD
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| BDBM50086201 |
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| n/a |
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| Name | BDBM50086201 |
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| Synonyms: | CHEMBL3425611 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25ClN4 |
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| Mol. Mass. | 428.957 |
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| SMILES | CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1ccccc1 |
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| Structure | 
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